5-FU/LVA commonly used combination treatment consisting of 5-fluorouracil and leucovorin
ABCC3Canalicular multispecific organic anion transporter 2
CRCColorectal cancer
DFSDisease Free Survival
dUMPmethylation of deoxyuridine-5′-monophosphate
FDAU.S. Food and Drug Administration
FOLFIRIA chemotherapy regimen made up of: FOL – Folinic acid (leucovorin), F – fluorouracil (5-FU) and IRI – Irinotican (Camptosar)
FOLFOXA chemotherapy regimen made up of : 5.fluorouracil, oxaliplatin and leucovorin
FPGSTetrahydrofolate synthase
GGHGamma-glutamyl hydrolase
GMPGood manufacturing practices (GMP) are the practices required in order to conform to the guidelines recommended by agencies that control authorization and licensing for manufacture and sale of food, drug products, and active pharmaceutical products.
HDMTXHigh doses of Methotrexate
i.v.Intra venous (injection)
INDInvestigational New Drug Application (for the FDA, US Drug Agency)
LC–MS/MSLiquid chromatography-mass spectrometry / mass spectrometry
Modufolin®Chemical name [6R]-5,10-methylenetetrahydrofolate, a novel folate-based compound developed to increase the efficacy and reduce the side effects of antimetabolites used in cancer treatment. It is the key active metabolite of all clinically used folate-based drugs today including leucovorin and levoleucovorin and therefore does not require metabolic activation.
MPASwedish Medical Product Agency
MTX/HDMTXMethotrexate / High Dose Methotrexate
ORROverall Response Rate
PCFTProton-coupled folate transporter or solute carrier family, member 1(SLC46A1)
PFSProgression Free Survival
PK/PDPharmacokinetics / Pharmacodynamics
SHMT-1Serine hydroxymethyltransferase
TSThymidylate synthase