Rescue therapy in osteosarcoma
Arfolitixorin can also be used as rescue therapy when treating osteosarcoma (bone cancer), which most commonly affects children and young people, acute lymphatic leukaemia (ALL), Burkitt’s lymphoma, and lymphomas of the central nervous system (lymphoma = cancer of the lymph glands). The cytotoxin, methotrexate, is used in higher doses to eliminate cancerous cells in these types of cancer. The high doses mean that there is also a risk of damage to the surrounding tissues, and leucovorin (reduced folate) is consequently given subsequently to rescue the healthy surrounding tissues. Arfolitixorin is also thought to be more effective than today’s treatment with leucovorin in conjunction with rescue therapy.